GENETIC PROFILING OF PRIMARY AND SECONDARY TUMORS FROM PATIENTS WITH LUNG ADENOCARCINOMA AND BONE METASTASES REVEALS TARGETED THERAPY OPTIONS

Genetic profiling of primary and secondary tumors from patients with lung adenocarcinoma and bone metastases reveals targeted therapy options

Abstract Background Patients newly diagnosed with lung adenocarcinoma B-3 with bone metastases (LABM) have poor survival rates after treatment with conventional therapies.To improve outcomes, we retrospectively investigated whether the application of a more comprehensive genetic test of tumor biopsies samples from LABM patients could provide the ba

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Cross-Regulation between the phz1 and phz2 Operons Maintain a Balanced Level of Phenazine Biosynthesis in Pseudomonas aeruginosa PAO1.

Gene duplication often provides selective advantages for the survival of microorganisms in adapting to varying environmental conditions.P.aeruginosa PAO1 possesses two seven-gene operons [phz1 (phzA1B1C1D1E1F1G1) and phz2 (phzA2B2C2D2E2F2G2)] that are involved in the biosynthesis of phenazine-1-carboxylic acid and its derivatives.Although the two o

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